Microsoft offers software licenses through a program called the Service Provider License Agreement. The SPLA model provides use of Microsoft products through a monthly user or processor based fee. SPLA software includes the Windows Operating System, Microsoft SQL Server, Microsoft Exchange Server, Microsoft SharePoint and shoutcast hosting, and many other server based products.
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For email marketers and email newsletter senders, the email domain will generally correspond with their website. This allows recipients to easily identify who the mail is coming from, or to easily reach the website. In other cases, recipients may be able to use a simple, straightforward email domain to reach a catch all mailbox in the case that they are unsure of their intended recipient’s email prefix.
Email hosting is a specialist internet hosting service which operates email servers. Hosting your email with one.com means you can benefit from premium services such as an ad-free interface, email on your own domain, spam and virus protection as well as black and white lists. Your email, calendar and contacts are also accessible via webmail in any browser, so your work can travel with you. 

Your next major concern will be compatibility. It's not a shock that most businesses run on Microsoft Windows and use some form of Microsoft Office. Being able to use common third-party clients such as Microsoft Outlook can often be a concern, and even today, compatibility with Microsoft Outlook isn't necessarily guaranteed. This is especially true when sending and receiving meeting invites. It only takes one garbled meeting invite to realize how frustrating this can be in the real world. Even if using Microsoft Outlook isn't a concern, portability is. If the service is entirely web-based, then is there a means for me to take my email offline and send email when I connect?
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